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KMID : 0981820100300010028
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Korean Journal of Laboratory Medicine
2010 Volume.30 No. 1 p.28 ~ p.33
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Antimicrobial Susceptibility Patterns of Legionella isolates in the Environment and in Patients
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Choi Go-Eun
Chang Chul-Hun L.
Kim Jung-Man
Lee Eun-Yup
Kang Jeong-Eun
Tateda Kazuhiro
Yamaguchi Keizo
Kim Kyung-Hee
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Abstract
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Background: Antimicrobial susceptibility of Legionella spp. has rarely been studied in Korea. Therefore, we aimed to determine the susceptibility of Legionella spp. to various antibiotics.
Methods: We assessed the antimicrobial susceptibility of 66 environmental and clinical Legionella isolates collected between January 2001 and December 2008 from Korea and Japan. The minimum inhibitory concentrations (MICs) of 6 antibiotics, namely, azithromycin, ciprofloxacin, clarithromycin, clindamycin, gatifloxacin, and gemifloxacin were determined by the broth microdilution method using buffered starch yeast extract broth.
Results: The MIC ranges of the 6 antibiotics used against the Legionella isolates were as follows: 0.004-0.062 mg/mL (azithromycin), 0.002-0.5 mg/mL (ciprofloxacin), 0.004-0.5 mg/mL (clarithromycin), 0.12-4 mg/mL (clindamycin), 0.002-0.12 mg/mL (gatifloxacin), and 0.008-1 mg/mL (gemifloxacin).
Conclusion: Legionella spp. isolates from Korea and Japan were most susceptible to gatifloxacin. Azithromycin, clarithromycin, ciprofloxacin, and gemifloxacin were also effective for treating legionellosis.
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KEYWORD
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Legionella, Antimicrobial susceptibility, Buffered starch yeast extract broth
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